At One Time the Uncoupler 2,4-Dinitrophenol Was Used as a Weight

question 4

Multiple Choice

At one time the uncoupler 2,4-dinitrophenol was used as a weight reducing drug.Its side-effects,including death,resulted in its discontinued use.How could this drug cause weight loss?

• A)The uncoupler allows the oxidation of fats from adipose tissue without the production of ATP.This allows the oxidation to proceed continuously and use up the fats.
• B)The uncoupler causes ATP to be produced at a much higher rate than normal and this causes weight loss.
• C)The uncoupler inhibits the transport of pyruvate into the matrix of the mitochondria.Fats are then degraded to glycerol and subsequently to pyruvate to provide the necessary energy,thereby depleting fat stores.
• D)The uncoupler is an allosteric activator of ATP synthase.This increases the rate of translocation of H+ and the oxidation of fuels,including fats.

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