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How Do the PKa Values of an Ionizable Side Chain

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How do the pKa values of an ionizable side chain compare when the amino acid is free versus when it is in a polypeptide chain?


Definitions:

Negative

In finance and economics, refers to a condition or a situation where the figures or the outcomes are less than zero, indicating a loss or decrease.

Decreasing

Refers to a process or trend where quantities or values are going down or diminishing over time.

Slope

In mathematics, a measurement of the steepness, incline, or grade of a line, typically expressed as a ratio of vertical change to horizontal change.

Value

The importance or utility that something has for an individual or the market price of a good or service.

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