Use the Following Scenario for the Following Questions

question 5

Multiple Choice

Use the following scenario for the following questions.
A few decades ago, Knudsen and colleagues proposed a theory that, for a normal cell to become a cancer cell, a minimum of two genetic changes had to occur in that cell. Knudsen was studying retinoblastoma, a childhood cancer of the eye.
-If there are two children born from the same parents, and child one inherits a predisposition to retinoblastoma (one of the mutations) and child two does not, but both children develop the retinoblastoma, which of the following would you expect?

• A)an earlier age of onset in child one
• B)a history of exposure to mutagens in child one but not in child two
• C)a more severe cancer in child one
• D)increased levels of apoptosis in both children
• E)decreased levels of DNA repair in child one

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