Why Is the Route of Administration Important to the "First-Pass

question 9

Multiple Choice

Why is the route of administration important to the "first-pass effect"?

• A)The route can help determine if the drug is being taken as prescribed and therefore is overcoming the first-pass effect.
• B)A drug can be significantly reduced to its inactive metabolite before first entering circulation when administered orally.
• C)Drugs administered parenterally are highly subject to the first-pass effect and should therefore be dosed accordingly.
• D)Bioavailability of drug can be greatly reduced when the drug is administered by a route other than orally.

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Definitions:

Holism

An approach or philosophy that emphasizes the importance of understanding systems or phenomena as wholes rather than solely through their individual components.

Disabilities

Conditions that impair, limit, or restrict an individual's physical or mental abilities.

Disfiguring

Causing physical damage or alteration to the appearance of something, often in a way that is considered unattractive or unpleasant.

Nature Dimension

Describes aspects of the physical environment and how they influence organisms and ecosystems.