Why Would the Efficacy of Levodopa Decrease Over Time

question 27

Multiple Choice

Why would the efficacy of levodopa decrease over time?

• A)Long-term use of levodopa creates a tolerance to the drug,decreasing its efficacy.
• B)Progressive desensitization of DA receptors requires an increased amount of DA to produce therapeutic effects.
• C)The mechanism by which levodopa is metabolized eventually becomes compromised because its constant levels in the brain decrease its efficacy.
• D)Levodopa eventually causes liver damage and is unable to be completely metabolized in the body decreasing its efficacy.

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Definitions:

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Linear Trend Line

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