How Does OnabotulinumtoxinA (BOTOX)therapeutically Produce Paresis in Overactive Muscles

question 5

Multiple Choice

How does onabotulinumtoxinA (BOTOX) therapeutically produce paresis in overactive muscles?

• A)Acts as an antagonist by binding to the ACh receptor on the postsynaptic membrane.
• B)Rapidly degrades ACh in the synaptic cleft.
• C)Facilitates the reuptake and sequestration of ACh into the presynaptic cell.
• D)Disrupts the protein structure of the muscle cell receptor,thus preventing ACh from binding.
• E)Inhibits the release of ACh from the presynaptic terminal at the neuromuscular junction.

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Definitions:

Postreinforcement Pause

A pause in responding that commonly occurs after the delivery of a reinforcer under certain schedules of reinforcement, such as a fixed ratio schedule.

FR-5 Schedule

A fixed-ratio schedule of reinforcement where a response is rewarded only after five instances of the behavior.

FR-15 Schedule

A fixed-ratio schedule of reinforcement where a response is reinforced only after it has been produced 15 times.

Fixed-Ratio

A reinforcement schedule where a response is reinforced only after a specified number of responses.