Fetal Hemoglobin Has a Somewhat Higher Oxygen-Binding Affinity Than Does

question 9

Multiple Choice

Fetal hemoglobin has a somewhat higher oxygen-binding affinity than does adult hemoglobin because:

• A)It has only one subunit, and therefore there is no cooperativity of oxygen binding.
• B)2,3-BPG binds less tightly to fetal hemoglobin than to adult hemoglobin, and this weakens its effect on the oxygen-binding affinity.
• C)The noncovalent interactions between the subunits are stronger in fetal hemoglobin than in adult hemoglobin.
• D)Fetal hemoglobin is less acidic than adult hemoglobin, and therefore it is less affected by increased acidity in the erythrocyte.
• E)The terminal amino groups of fetal hemoglobin are chemically modified, and therefore they cannot react with carbon dioxide.

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