In Which Way Is the Transition State of an Enzyme-Catalyzed

question 19

Multiple Choice

In which way is the transition state of an enzyme-catalyzed reaction different from the transition state of the corresponding uncatalyzed reaction?

• A)It has a higher free energy content.
• B)It has less chemical stability and is therefore more reactive.
• C)It is more similar to the conformation of the substrate, as a result of induced fit.
• D)It is energetically more stable, because it makes favorable interactions with the enzyme.
• E)It participates in the reaction by exchanging a proton with the substrate, in a process that is known as general acid-base catalysis.

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