In Sickle Cell Anemia, the Replacement of Glutamate by Valine

question 7

Multiple Choice

In sickle cell anemia, the replacement of glutamate by valine in position 6 of the β chain leads to serious trouble.Which of the following amino acid changes at position 6 would cause only a minimal change in the properties of hemoglobin?

• A)Glutamate to aspartate.
• B)Glutamate to proline.
• C)Glutamate to isoleucine.
• D)Glutamate to methionine.
• E)Glutamate to tryptophan.

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