In the Following Family, I-2 and II-1 Have Died from a Rare

question 2

Multiple Choice

In the following family, I-2 and II-1 have died from a rare form of colon cancer that is inherited as an autosomal dominant trait.The remaining family members have undergone genotyping for a microsatellite marker close to the known gene for colon cancer susceptibility.According to this analysis, what are the genotypes of the children in the third generation (left to right; the term carrier is used for a person who has the genetic disposition but has not yet developed the disease) ?

• A)Carrier, normal, carrier, normal.
• B)Carrier, normal, normal, carrier.
• C)Normal, carrier, normal, carrier.
• D)Normal, carrier, carrier, normal.
• E)Normal, carrier, normal, normal.

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Definitions:

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