In the Following Family, I-2 and II-1 Have Died from a Rare

question 2

Multiple Choice

In the following family, I-2 and II-1 have died from a rare form of colon cancer that is inherited as an autosomal dominant trait.The remaining family members have undergone genotyping for a microsatellite marker close to the known gene for colon cancer susceptibility.According to this analysis, what are the genotypes of the children in the third generation (left to right; the term carrier is used for a person who has the genetic disposition but has not yet developed the disease) ?

• A)Carrier, normal, carrier, normal.
• B)Carrier, normal, normal, carrier.
• C)Normal, carrier, normal, carrier.
• D)Normal, carrier, carrier, normal.
• E)Normal, carrier, normal, normal.

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Definitions:

Profit Margin

A financial ratio indicating the percentage of revenue that exceeds the cost of goods sold, representing the proportion of each dollar of revenue that constitutes net profit.

ROA

Return on Assets, a financial ratio indicating how profitable a company is relative to its total assets.

IFRS

International Financial Reporting Standards, a set of accounting standards developed by the International Accounting Standards Board (IASB) that companies use for financial reporting.

GAAP

General Accepted Accounting Principles, which are a set of accounting standards and procedures used in the US to ensure consistency in financial reporting.