A Bone Marrow Core Biopsy Is Received on a 10-Year-Old

question 11

Multiple Choice

A bone marrow core biopsy is received on a 10-year-old male patient suspected of having aplastic anemia. The pathologist reviews the smear and concludes the overall cellularity to be 22% with an M:E ratio of 2.5:1. Is the patient likely suffering from aplastic anemia? Why or why not?

• A) There is not enough information to determine whether the patient has aplastic anemia.
• B) Yes, the patient is presumably suffering from aplastic anemia, but the M:E ratio does not correlate well with that diagnosis.
• C) No, the patient is not suffering from aplastic anemia because the overall cellularity is increased.
• D) Yes, the patient is presumably suffering from aplastic anemia because of the low overall cellularity and the normal M:E ratio.

Calculate probabilities using the Normal model and determine when its use is appropriate.

Assess the distribution of proportions in population samples and their implications.

Apply binomial and Normal distribution concepts to practical examples.

Analyze situations requiring the adjustment of standard distributions to fit real-life data.

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Definitions:

Brain

The organ located in the head of an organism that coordinates its actions and sensory information by transmitting signals to and from different parts of its body.

Auditory Nerve

A nerve in the inner ear that transmits sound information from the cochlea to the brain.

Neurons

Specialized cells in the nervous system that transmit information via electrical and chemical signals.

Temporal Lobe

A region of the cerebral cortex responsible for processing auditory information and encoding memory.