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B-Lactamases Hydrolyze B-Lactam Antibiotics Using Two Distinct Mechanisms: Those Having

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b-Lactamases hydrolyze b-lactam antibiotics using two distinct mechanisms: those having a metallo-based mechanism of action and those with:


Definitions:

Ultradian Rhythm

Biological rhythms with a cycle shorter than 24 hours, such as stages of sleep or the pattern of hormonal release.

Free-Running Rhythm

Rhythm of the body’s own devising in the absence of all external cues.

Zeitgeber

Environmental event that entrains biological rhythms; German for “time giver.”

Entrained

The synchronization of an organism's circadian rhythms to that of an external rhythm in its environment.

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