Alagille Syndrome Involves a Failure of Proper Segmentation of the Paraxial

question 7

Multiple Choice

Alagille syndrome involves a failure of proper segmentation of the paraxial mesoderm,ultimately resulting in defects of the vertebral column.Which signaling pathway is mutated in patients with Alagille?

• A) Notch-Delta
• B) TGF-beta
• C) Tyrosine Kinase
• D) Ephrin-EPH
• E) Integrin

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Definitions:

Nodular Lesions

Small, rounded masses or lumps of abnormal tissue, often found in organs or the skin, which can be benign or malignant.

Pulmonary Fibrosis

A lung disease that occurs when lung tissue becomes damaged and scarred, causing severe breathing difficulties and reduced oxygen supply to the bloodstream.

Asbestosis

A lung disease resulting from the inhalation of asbestos particles, causing scarring of lung tissue.

Common Cold

A viral infectious disease of the upper respiratory tract that primarily affects the nose, throat, sinuses, and larynx, leading to symptoms like coughing and sneezing.