A 4-Year-Old-Girl Sees Her Physician Because of a Severe Necrotizing,oropharyngeal $\gamma$

question 6

Multiple Choice

A 4-year-old-girl sees her physician because of a severe necrotizing,oropharyngeal herpes simplex viral (HSV) infection.She has a past medical history of cytomegalovirus (CMV) pneumonitis and cutaneous HSV infection.Phenotypic analysis of her blood cells shows an absence of CD56⁺ and CD16⁺ cells.There are normal numbers of CD4⁺ and CD8⁺ cells in the blood,and serum antibody titers are normal.The patient's CD8⁺ T cells were able to kill virally infected target cells in vitro.Which of the following is NOT characteristic of this girl's immunodeficiency disease?

• A)Lack of cells whose activation is normally inhibited by self class I major histocompatibility complex (MHC)
• B)Impaired granzyme B-dependent killing of virally infected target cells
• C)Lack of cells that are activated by IL-15
• D)Impaired interferon (IFN)-\(\gamma\) production during early phases of viral infection
• E)Failure to form viral peptide-class I MHC complexes