Transgenic Mouse Lines Have Been Very Useful for the Study

question 11

Multiple Choice

Transgenic mouse lines have been very useful for the study of mechanisms of self-tolerance.In one such line,transgenes were introduced encoding a T cell receptor (TCR) specific for the H-Y antigen,which is a protein expressed by many cell types only in male mice.When these transgenic mice were analyzed,researchers found that T cells expressing the H-Y-specific TCR developed normally in female mice but not in male mice.This finding illustrates which of the following mechanism of self tolerance?

• A)Peripheral anergy
• B)Central (thymic)deletion
• C)Clonal ignorance
• D)Regulatory T cell-mediated suppression
• E)Peripheral deletion

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Definitions:

Status Variables

Variables that indicate or reflect an individual's social or professional position, often used in research to examine effects of social status on various outcomes.

Psychological Treatments

Therapeutic interventions designed to address and alleviate mental health issues primarily through verbal communication, behavior modification, and cognitive restructuring.

Independent Variable

The variable in an experiment that is manipulated or changed to observe its effect on the dependent variable.

Placebo Treatment Group

A group of participants in a research study who receive a sham or inert treatment, allowing researchers to measure the placebo effect.