Class I MHC-Restricted T Cell Responses to Tumors Can Be

question 2

Multiple Choice

Class I MHC-restricted T cell responses to tumors can be demonstrated in patients with various types of tumors,yet most of these tumors do not express costimulatory molecules.Which mechanism most likely explains how naive CD8⁺ T cells specific for antigens expressed by these tumors are stimulated to differentiate into cytolytic T lymphocytes?

• A)Malignant transformation of CD8⁺ T cells
• B)Tumor secretion of T cell-activating cytokines
• C)Cross reaction of microbe-specific CD8⁺ T cells with tumor antigens
• D)Cross priming
• E)Antigenic modulation

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