Mary,a 7-Year-Old,was Admitted to the Hospital After Experiencing Severe Anemia

question 17

Multiple Choice

Mary,a 7-year-old,was admitted to the hospital after experiencing severe anemia following a respiratory infection.Her father has a history of RBC membrane abnormality and recently underwent a splenectomy to help alleviate the problem.Upon examination,it was revealed that Mary had hepatosplenomegaly and slight bruising on her forearms.A CBC was ordered,with the following results: HGB 9.0 g/dL
HCT 24%
WBC 11 × 10⁹/L
RBC 3.8 × 10¹²/L
MCV 102 fl
MCH 25 pg
MCHC 40%
PLT 275 × 10⁹/L
Peripheral smear: moderate macrocytes and stomatocytes
Which of the following is most consistent with a presumptive diagnosis in this case?

• A)PNH
• B)HS
• C)DHS
• D)HE

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