A Significant Polymorphic Inversion on Chromosome 17, the MAPT Inversion

question 1

Multiple Choice

A significant polymorphic inversion on chromosome 17, the MAPT inversion, is identified by marker SNPs that can now be used to screen large numbers in a population. The inverted region is large and extends for approximately 900 kb. The two haplotypes (one inverted and one not) are each associated with increased risk of a number of neurological conditions. How can the inverted region be used to find the most recent common ancestor of the inversion?

• A)by typing SNPs from humans and from other primates
• B)by assessing SNPs from a large number of human populations
• C)by looking for heterozygotes for the two kinds of chromosome 17
• D)by fertility studies on populations with each of the haplotypes
• E)by using a BAC clone library to identify the ends of the inversion

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Definitions:

MC

The additional cost incurred by producing one more unit of a product or service, commonly known as marginal cost.

ATC

Stands for Air Traffic Control, a service provided to direct aircraft safely in the sky and on the ground.

Output Q3

A specific reference to the quantity of goods or services produced in the third quarter of a financial or calendar year.

Lowest Cost

The minimum expense incurred in producing or offering a good or service, often emphasized as a competitive advantage in markets.