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Trisomy 21,or Down syndrome,occurs when there is a normal diploid chromosomal complement but one (extra) chromosome 21.Although fertility is reduced in both sexes,females have higher fertility rates than males.Van Dyke et al.(1995; Down Syndrome Research and Practice 3(2) : 65-69) summarize data involving children born of Down syndrome individuals.Assume that children are born to a female with Down syndrome and a normal 46-chromosome male.What proportion of the offspring would be expected to have Down syndrome?
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