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CASE HISTORY Michael,45 Years Old,is a Cook at a Fast-Food Restaurant in Restaurant

question 30

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CASE HISTORY
Michael,45 years old,is a cook at a fast-food restaurant in Rome,Georgia.He went to see his physician because he was feeling fatigued,was unable to sleep,had lost his appetite,and had been coughing for several weeks.His sputum (material coughed from deep in the lung) contained acid-fast bacilli,and a chest X-ray revealed scattered,small (1-5 mm) granulomas (nodules of inflammation) throughout both lobes of the lung.The physician diagnosed Michael with secondary tuberculosis.Secondary tuberculosis is caused by bacteria reactivated from old lesions in which bacteria have persisted in a dormant state.The causative bacterium is Mycobacterium tuberculosis,a facultative intracellular pathogen that infects only humans and is transmitted through respiratory droplets.Michael was placed in isolation and started on a long-term,four-drug treatment regimen consisting of isoniazid (fatty acid synthesis inhibitor) ,rifampin (transcription inhibitor) ,pyrazinamide (fatty acid synthesis inhibitor) ,and streptomycin (protein synthesis inhibitor) .The four-drug therapy continued for two months,followed by four months with isoniazid and rifampin only.Michael responded well to treatment.Luckily,he was not infected with one of the highly dangerous multidrug-resistant strains (MDr-tB) .
Mycobacterium tuberculosis is a member of the Actinobacterium,which causes disease in humans,though other members of this group are environmental microorganisms and some produce useful antibiotics.Which other Actinobacterium is a pathogen of humans?

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