How Does Pharmacodynamic Tolerance Develop

question 23

Multiple Choice

How does pharmacodynamic tolerance develop?

• A) The most acute effect of alcohol occurs after the first few drinks in a day; because the liver can only process so much alcohol, these effects become less pronounced as more drinks are consumed.
• B) Over sustained periods of using alcohol, the number or sensitivity of the neuroreceptors that respond to alcohol gradually decreases.
• C) Sustained use of alcohol over months or years increases the sensitivity of GABA and dopamine receptors.
• D) The amount of substance that can be used in a given period of time fluctuates based on circadian cycles and, in women, menstrual cycles.