All of the Following Can Describe Why ED₅₀ and TD₅₀

question 112

Multiple Choice

All of the following can describe why ED₅₀ and TD₅₀ values are not ideal for calculating a therapeutic index except:

• A) the index uses a value based on 50% of subjects experiencing severe adverse effects.
• B) the index uses a value based on only 50% of subjects experiencing therapeutic drug effects.
• C) the index uses the ED₅₀ value, which is most common for reporting dose-effect curves.
• D) no matter the size of the index, using 50% values suggests that an unacceptable number of patients will likely experience adverse effects.

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