Why Might a Study Drug Fail to Proceed from Phase

question 88

Multiple Choice

Why might a study drug fail to proceed from Phase 2 to Phase 3 clinical trials?

• A) The drug produced too many adverse effects.
• B) The drug did not appear to be effective.
• C) The drug was not more effective than drugs already on the market.
• D) All of these answers are correct.

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Definitions:

Paired Observations

Data collected in pairs such that each observation in one group is related or matched to an observation in another group.

Spearman Rank Correlation

An unparametric method for determining rank correlation that evaluates the extent to which two variables' relationship can be characterized by a monotonic function.

Ordinal Variables

Variables that represent categories with a natural order but which do not have a fixed interval between values, allowing for ranking but not quantifiable difference measurement.

Interval Variables

Variables that have meaningful distances between measurements but do not have a true zero point, allowing for both positive and negative values.