If a Drug Was Present in the Bloodstream but Unable

question 47

Multiple Choice

If a drug was present in the bloodstream but unable to cross the blood-brain barrier,then one could conclude:

• A) that nonspecific binding occurred.
• B) the drug could enter the brain using active transport mechanisms.
• C) the drug's pKa had matched the pH of the physiological medium it was administered in.
• D) the drug was not small, non-charged or lipid soluble.

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Definitions:

Eukaryotes

Organisms with cells that contain a nucleus enclosed within membranes.

DNA Pol III

An enzyme involved in DNA replication, responsible for synthesizing new strands of DNA in bacteria.

Polynucleotide Chain

A biopolymer composed of 13 or more nucleotide monomers covalently bonded in a sequence, forming part of the structure of DNA and RNA.

Nucleotide Excision Repair

A DNA repair mechanism that removes and correctly replaces a damaged DNA segment in the genome.