How Do Extrapyramidal Side Effects Occur from Antipsychotic Medications If

question 91

Multiple Choice

How do extrapyramidal side effects occur from antipsychotic medications if dopamine neurons are overactivated in schizophrenia?

• A) After antipsychotics bind to D₂ receptors in the limbic system, most drug molecules are left for blocking receptors in the basal ganglia.
• B) Antipsychotics have a stronger affinity for dopamine receptors in the basal ganglia.
• C) Mesolimbic neurons are overactivated in schizophrenia, but nigrostriatal neurons are not.
• D) Inhibition of glutamate neurons in turn causes an inhibition of nigrostriatal neurons.

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Definitions:

COC Bond Angle

Refers to the angle between two carbon atoms and an oxygen atom within certain molecular structures, important in chemical bonding.

Pi Bonds

Covalent chemical bonds where two lobes of one involved atomic orbital overlap two lobes of the other involved atomic orbital, forming a bond that is parallel to the bonding axis and allowing for electron sharing.

RU-486

A synthetic steroid used medically to induce abortion by blocking the action of progesterone.

Cis-trans Isomers

Stereoisomers that differ in the spatial arrangement of groups relative to a double bond, ring, or other structure leading to different physical and chemical properties.