Papillomaviruses Replicate in Differentiated Keratinocytes, Which Are Not Actively Dividing

question 22

Multiple Choice

Papillomaviruses replicate in differentiated keratinocytes, which are not actively dividing.How does the virus handle this situation?

• A) They encode their own DNA replication enzymes.
• B) Plasmid replication in the basal cells produces enough copies of the viral genome.
• C) The viral E2 protein directly activates transcription of DNA replication genes.
• D) The viral E6 protein binds to the p53 protein, causing it to be degraded.
• E) The viral E7 protein binds to the pRb protein, forcing the cell into S phase.

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