Which of the Following Experiments Demonstrates That PrPᶜ Is Required

question 13

Multiple Choice

Which of the following experiments demonstrates that PrPᶜ is required for prion disease transmission?

• A) Mice with the hamster PrP gene are susceptible to hamster prions.
• B) Mice lacking the Prp gene are resistant to prion infections.
• C) Yeast have proteins that can form self-propagating states like prion proteins.
• D) The PrPˢᶜ protein has the same amino acid sequence as the PrPᶜ protein.
• E) Injection of brain extracts from kuru patients into monkeys causes the monkeys to get a similar disease.

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