The Genetic Forms of Prion Diseases Result from Mutations in the Prion

question 15

Multiple Choice

The genetic forms of prion diseases result from mutations in the prion gene.What is the proposed mechanism for how these mutations cause the prion disease?

• A) They cause the prion protein to become degraded in the cell.
• B) They stabilize the structure of the PrPᶜ form of the protein.
• C) They lead to overexpression of the prion protein in the brain.
• D) They cause the prion protein to misfold more easily into the PrPˢᶜ form.
• E) They cause the prion protein to interact with the microtubules in the neuron.

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