[Solved] "Please explain the pathophysiology of osteoarthritis to me," says another nurse."Is it just wear and tear so that the cartilage wears out?" Your best response is A) "Yes; repeated use just wears out the cartilage, until it becomes thin and denuded. That causes pain and will eventually cause joint inflammation." B) "Yes; with increasing age, the inflammation from repeated joint use accumulates and causes the cartilage to get thin and ragged until it disappears." C) "No; cells in bone, cartilage, and the synovial membrane all get activated and secrete inflammatory mediators that destroy cartilage and damage bone." D) "No; autoimmune cells infiltrate the joint and collect on the cartilage in a mass called 'pannus' that eventually thins and destroys the cartilage." HR Forecasting Document: A strategic document used by human resources to predict future HR needs, including staffing requirements and skill shortages. Resistance To Change: The reluctance or refusal to adapt to changes in the workplace or operational environments, often due to fear of the unknown or loss of status or job security. Organizational Change: the process through which a company or organization changes its structure, strategies, operational methods, or culture to improve efficiency and effectiveness. Cynicism: A negative attitude or skepticism towards something, often marked by a lack of trust or belief in its value or truth.