The Reverse Transcription of HIV RNA Utilizes Host Cell TRNA

question 22

Multiple Choice

The reverse transcription of HIV RNA utilizes host cell tRNA as a primer. Specifically, a tRNA for lysine is utilized. Would a drug that blocked the host cell synthesis of the tRNA for lysine be a good drug to prevent the HIV life cycle?

• A) Yes, it should stop the reverse transcription of the HIV genome with few side effects.
• B) No, the virus would just use a different tRNA for priming.
• C) No, this would likely kill the cells that were drug treated, because they couldn't appropriately incorporate lysine into their proteins.
• D) No, the priming function of the tRNA is not essential for the HIV life cycle.

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