SMAD4 Is a Tumor Suppressor Gene Located on Chromosome 18

question 22

Multiple Choice

SMAD4 is a tumor suppressor gene located on chromosome 18 that is known to be homozygously deleted in human lung cancer. If you were to perform comparative genomic hybridization with tissue from a lung cancer patient with a homozygous negative SMAD4 tumor, what ratio of green to red fluorescence would you expect?

• A)A ratio of 1 on all of chromosome 18.
• B)A ratio of 2 on the part of chromosome 18 containing the SMAD4 gene, with a value of 1 on the remainder of the chromosome.
• C)A ratio of 0 on all of chromosome 18.
• D)A ratio of 0 on the part of chromosome 18 containing the SMAD4 gene, with a value of 1 on the remainder of the chromosome.
• E) A ratio of 1 on the part of chromosome 18 containing the SMAD4 gene, with a value of 0 on the remainder of the chromosome.
• F)
• A ratio of 0.5 on the part of chromosome 18 containing the SMAD gene, with a value of 1 on the remainder of the chromosome.

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