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The African clawed frog (Xenopus laevis) is allotetraploid, likely as a result of an interspecies mating long ago, followed by a duplication of the entire genome. Xenopus laevis is fertile and has a normal life cycle. In contrast, mules, the allodiploid offspring of a male donkey and a female horse, are generally sterile. Why can Xenopus reproduce and mules cannot?
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