Efflux Pumps Send Antibiotics Such as Tetracycline, Which Binds to the 30S

question 33

Multiple Choice

Efflux pumps send antibiotics such as tetracycline, which binds to the 30S subunit of bacterial ribosomes, out of the bacterial cells, enabling them to grow in the presence of antibiotics. Which of the following therapeutic approaches will be least effective?

• A) Switch to an antibiotic that is not a substrate of the efflux pump.
• B) Augment the treatment with an efflux inhibitor.
• C) Increase the concentration of tetracycline.
• D) Augment the treatment with an ATP synthase inhibitor.
• E) None of the above approaches will be effective.

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Definitions:

Dopamine Synapses

The junctions between neurons where dopamine, a neurotransmitter associated with pleasure and reward, is transmitted.

Muscular Rigidity

A condition characterized by stiffness of the muscles, seen in various neurological and psychiatric disorders.

Tremors

Involuntary, rhythmic muscle contractions leading to shaking movements in one or more parts of the body, often a symptom of neurological conditions.

Drowsiness

A state of feeling abnormally sleepy or tired, which can be a symptom of various medical conditions or a side effect of medications.