Examlex
The BEST time to establish reasonable controls is:
Mutations
Changes in the DNA sequence of an organism's genome, which can lead to variations in phenotype and can be inherited by future generations.
Rare Genetic Diseases
Disorders caused by changes in genes or chromosomes, often with low prevalence in the general population but with significant impacts on those affected.
Bottlenecks
Events that drastically reduce the size of a population, leading to loss of genetic variation and increasing the influence of genetic drift.
Inbreeding
The breeding or mating of closely related individuals, which can lead to an increased chance of offspring inheriting genetic disorders or traits.
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