Many Antibiotics,most of Which Have Been Isolated from Fungi,act by Inhibiting

question 44

Essay

Many antibiotics,most of which have been isolated from fungi,act by inhibiting initiation,elongation,or termination of peptides during protein synthesis.These compounds have been very useful in the study of protein synthesis,mainly because an individual antibiotic usually interferes with protein synthesis at a single well-defined step in the complex process of translation.Assume that you have isolated a novel antibiotic from the fungus Pilobolus.This antibiotic inhibits bacterial growth and bacterial protein synthesis but does not affect growth or protein synthesis in eukaryotic cells.How could you identify the component of the translational machinery that is affected by this novel antibiotic?

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