In Yeast,U2 SnRNA Base-Pairs to a Short Sequence near Branch-Point

question 27

Essay

In yeast,U2 snRNA base-pairs to a short sequence near branch-point A in introns.In higher eukaryotes,this branch-point sequence is not highly conserved,and a protein called U2AF promotes binding of U2 snRNA to pre-mRNA.You have produced mice with a knockout mutation in the U2AF gene.Would you expect mice heterozygous for the U2AF knockout mutation to be viable? Would you expect mice homozygous for the U2AF knockout mutation to be viable?

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