The Order of Events in a Signaling Pathway Can Be

question 24

Multiple Choice

The order of events in a signaling pathway can be determined by the analysis of mutants.Cells that express a mutant defective Raf protein cannot be stimulated to proliferate uncontrollably by constitutively active Rasᴰ (dominant active) .This indicates:

• A)quiescent cells can be induced to proliferate in the absence of growth factors if they contain a constitutively inactive mutant Raf protein.
• B)Raf is upstream of Ras in the signaling pathway.
• C)Ras is upstream of Raf in the signaling pathway.
• D)Ras mutants are recessive to Raf mutants.

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Definitions:

Equity

The value of ownership interest in property, including shareholders' equity in a corporation, minus liabilities and debts.

Concealment

The active hiding of the truth about a material fact.

Material Fact

A fact that is significant or essential to the issue or matter at hand, especially in the context of contracts or litigation.

Mistake Of Fact

An error made regarding a fact that is material to a contract, which can affect the validity of the contract if the mistaken belief was a basis for its formation.