In Mice Engineered to Overexpress the Syndecan-1 Gene in the Hypothalamic Region

question 39

Multiple Choice

 In mice engineered to overexpress the syndecan-1 gene in the hypothalamic region of the brain and other tissues,normal control of feeding by antisatiety peptides is disrupted,and the animals overeat and become obese.Other studies have shown that syndecan-3 may also be involved in the regulation of feeding behavior.Given the following information,which of these outcomes might you expect in experimentally manipulated mice?
Hypothalmic expression of syndecan-3 is increased by fasting.
Syndecan-3 knockout mice are resistant to diet-induced obesity.
Heparinase can cleave syndecan-3 to release heparin sulfate GAG chains that may suppress the activity of antisatiety peptides and feeding behavior.

• A)Overexpression of heparinase in mice with normal levels of syndecan-3 would result in resistance to diet-induced obesity.
• B) In mice with normal levels of syndecan-3,fasting followed by free access to a high-fat diet would lead to resistance to diet-induced obesity.
• C)Lack of heparinase in mice with normal levels of syndecan-3 would result in animals that overeat and become obese.
• D)Overexpression of heparinase in syndecan-3 knockout mice would reverse the resistance to diet-induced obesity.
• E)There are two plausible hypotheses: 1)Overexpression of heparinase in mice with normal levels of syndecan-3 would result in resistance to diet-induced obesity;and 2)lack of heparinase in mice with normal levels of syndecan-3 would result in animals that overeat and become obese.

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Definitions:

Co-occur

The simultaneous presence or occurrence of two or more conditions or phenomena, often used in the context of diseases or disorders that appear together in patients.

Personality Disorders

A class of mental health disorders characterized by enduring maladaptive patterns of behavior, cognition, and inner experience, exhibited across many contexts and deviating from those accepted by the individual's culture.

Somatic Symptom

A physical symptom that can be experienced as part of a mental disorder but has no identifiable physical cause.

Masked

Concealed or hidden, often used to describe data or information that has been anonymized or altered to prevent identification of individual sources.