What Is the Pathophysiologic Process in Hemolytic-Uremic Syndrome

question 2

Multiple Choice

What is the pathophysiologic process in hemolytic-uremic syndrome?

• A) An autoimmune disorder in which immunoglobulin A (IgA)coats erythrocytes that are destroyed by the spleen and remnants are excreted through the kidneys.
• B) Verotoxin from E.coli is absorbed from the intestines and damages erythrocytes and endothelial cells.
• C)Endotoxins from E.coli block the erythropoietin produced by the kidneys,which reduces the number of erythrocytes produced by the bone marrow.
• D)Failure of the nephron to filter urea increases the blood urea nitrogen,which binds to erythrocytes that are subsequently destroyed by the spleen.

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