In Osteoarthritis,what Is the Effect of the Disruption of the Pumping

question 27

Multiple Choice

In osteoarthritis,what is the effect of the disruption of the pumping action of proteoglycans?

• A) Pump malfunction stimulates the induction of nitric oxide synthase (iNOS)and nitric oxide (NO),which degrade the cartilage.
• B) Cartilage is damaged by proteolytic enzymes because they cannot be pumped out of the joint.
• C) Cartilage becomes dry,brittle,and wears away because fluid cannot be pumped into the cartilage.
• D) Cartilage takes in too much fluid and is unable to withstand the stresses of weight bearing.

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