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A strain of N.gonorrhoeae is isolated that does not have a plasmid.If a lysate is made from the bacterium it cannot degrade penecillin in an in vitro assay.When a cuture of this strain is grown in a solution that contains radioactive penicillin the amount of penecilllin found within cells is less than the amount found in a non-resistant strain.Sequence of the porin gene from the resitant strain does not have any mutations.What is the most likely mechanism of resistnace in this strain?
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