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Tetrodotoxin Is a Heat-Stable Molecule Produced by Puffer Fish That

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Tetrodotoxin is a heat-stable molecule produced by puffer fish that blocks the entry of sodium ions into neurons. About 10-45 minutes after ingestion of tetrodotoxin, tingling of the tongue and inner surface of the mouth begins. An ascending paralysis develops, and death can occur within 6-24 hours, after respiratory muscle paralysis.
-Why would this lead to paralysis and death?


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