Cystic Fibrosis (CF)is an Inherited Disorder That Is Caused by a Mutation

question 12

Multiple Choice

Cystic fibrosis (CF) is an inherited disorder that is caused by a mutation that prevents various ions from moving across cell membranes.Normally there are proteins that allow passage of the ions,but in CF these proteins seemed to be disabled.Researchers have found that one explanation of this has to do with

• A)the chaperone proteins are missing or are not functioning and,thus,the correct folding of the proteins are prevented from occurring.
• B)the proteins are denatured and as a result become disabled,which prevents the correct interface with the substrate,effectively blocking ion transfer.
• C)the chaperone proteins are bound with the ions at the cell membrane surface and cannot release to aid the unfolded proteins.
• D)the proteins are disabled because of the pH change at the cell membrane surface caused by the accumulated ions.
• E)the chaperone proteins and the proteins are unable to segregate themselves because of the lower pH environment produced by the ionic gradient created on the cell membranE.

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Definitions:

Interdependency

A mutual reliance between two or more groups, systems, or entities where each affects or depends on the other.

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