Pufferfish (Fugu)are a Delicacy in Japan,but Must Be Cleaned Very

question 23

Multiple Choice

Pufferfish (Fugu) are a delicacy in Japan,but must be cleaned very carefully as their liver contains tetrodotoxin which blocks voltage-gated Na⁺ channels.Imagine you are testing for the presence of this toxin using a neuron in a dish.You apply an electrical stimulus to the neuron that should produce an action potential.What will you observe if tetrodotoxin levels are high enough to block the neuron's voltage-gated Na⁺ channels?

• A)The neuron will exhibit a slow depolarization even before the stimulus is applied,followed by a normal action potential.
• B)The neuron will exhibit a slow hyperpolarization even before the stimulus is applied.
• C)The neuron will show a normal resting potential,but will not exhibit depolarization when the stimulus is applied.
• D)The neuron will exhibit rapid depolarization,but will not repolarize.
• E)The neuron will depolarize normally,but then become hyperpolarized such that the membrane potential is much lower than usual.

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