The ΔG˚′ =-21 KJ Mol^-1 for the Reaction Catalyzed by Isocitrate

question 31

Essay

The ΔG˚′ =-21 kJ mol^-1 for the reaction catalyzed by isocitrate dehydrogenase, yet the ΔG˚′ = +29.7 kJ mol^-1 for the reaction catalyzed by malate dehydrogenase. Both of these reactions involve the oxidation of a secondary alcohol. Give an explanation as to why the oxidation of isocitrate is so exergonic.

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