How Can the Leading and Lagging Strands Be Synthesized in a Coordinated

question 22

Multiple Choice

How can the leading and lagging strands be synthesized in a coordinated fashion?

• A) Specific enzymes control the size of the DNA opening.
• B) Lagging-strand binding proteins inhibit leading-strand replication if the strands become disproportionate in size.
• C) DNA polymerase III is a dimeric holoenzyme, and the looped lagging strand allows the enzyme to proceed in the same direction with each strand.
• D) Leading and lagging strand syntheses are catalyzed by two distinct and noninteracting replisomes, but the rate is controlled by helicase.
• E) None of the answers is correct.

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