First Attempts to Develop Cholesterol-Lowering Drugs Targeted the Later Steps

question 4

Multiple Choice

First attempts to develop cholesterol-lowering drugs targeted the later steps in cholesterol biosynthesis. Why did this strategy have to be abandoned?

• A) These reactions were so efficient that they could not be blocked.
• B) The accumulation of an insoluble substrate caused cataracts and other deleterious side effects.
• C) All of the drugs that were developed actually enhanced cholesterol synthesis.
• D) None of the drugs that were developed could survive the acid conditions in the stomach.
• E) These drugs caused untreatable gall stones.

---

Definitions:

Onset of Seizures

The initiation or beginning phase of a seizure, marked by sudden, abnormal electrical activity in the brain, leading to various physical symptoms.

Chronic Traumatic Encephalopathy (CTE)

A brain condition associated with repeated head injuries leading to long-term neurodegenerative issues.

Neural Changes

Refers to the alterations in neural pathways and synapses that occur due to growth, learning, or injury, affecting how the brain processes information.

Antidepressant Drugs

Medications used to treat depression and other conditions by adjusting levels of neurotransmitters in the brain.