Why Would You Expect Acyclovir to Be Ineffective Against Latent

question 41

Multiple Choice

Why would you expect acyclovir to be ineffective against latent HSV infections?

• A) This is an antibacterial drug, and HSV is a virus.
• B) This is an antifungal drug, and HSV is a virus.
• C) This drug directly inhibits DNA polymerase activity-cells that are latently infected with HSV have no DNA polymerase activity.
• D) This drug is a nucleoside analogue-it becomes activated by a viral enzyme that is produced only when the virus is replicating. As such, if the virus is latent, the enzyme to activate the drug is not present (and the drug is ineffective).

---

Definitions:

Neuroticism

A personality trait characterized by emotional instability, anxiety, moodiness, irritability, and sadness.

Temperament

The aspect of an individual's personality concerned with emotional dispositions and reactions, often evident from infancy.

Adoptive Families

Households where one or more of the children has been legally taken and raised by caregivers who are not their biological parents.

Biological Siblings

Siblings who share both biological parents and have a genetic connection, as opposed to siblings connected by adoption or step-relations.