Explain How Using a Combination of Two Antimicrobial Drugs Helps

question 32

Multiple Choice

Explain how using a combination of two antimicrobial drugs helps prevent the development of spontaneously resistant mutants.

• A) All drugs work synergistically with each other-that is, their combined effects are far greater than either could achieve individually. Two drugs together helps to eliminate microbes, even if they have developed spontaneous mutations that would confer upon them resistance to the drugs.
• B) It is highly unlikely that the microbe might spontaneously develop 2 specific mutations to resist the effects of a pair of drugs. As such, even if one drug is resisted by the microbe, the 2nd drug will eliminate the mutated microbe, thus preventing the development of spontaneously resistant mutants overall.
• C) All drugs work antagonistically with each other-that is, their combined effects are far greater than either could achieve individually. Two drugs together helps to eliminate microbes, even if they have developed spontaneous mutations that would confer upon them resistance to the drugs.
• D) Drugs can also select for mutations that will enhance the activity of another drug. So, each of the paired drugs will help to select for spontaneous mutations that enhance the activity of the other drug in the pair.

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Definitions:

Statistically Significant

A determination that a relationship between two or more variables is caused by something other than chance.

High-Variation Population

A population with a wide range of characteristics or outcomes, indicating significant diversity or differences among its members.

Sample Size

The number of observations or data points used in a statistical sample, which determines the accuracy and reliability of the study's findings.

Statistically Significant

A measure indicating that the likelihood that a result or relationship is caused by something other than mere random chance is high.